High-Dose Toremifene as a Promising Candidate Therapy for Hormone Receptor-Positive Metastatic Breast Cancer with Secondary Resistance to Aromatase Inhibitors

Table 4

Drug cost per month in each common endocrine therapy in Japan on March 2019.

Endocrine therapy	Regimen	Common side effects	Drug cost per 28 days (generic drug)
TAM	Tamoxifen 20 mg/day	Hot flash, thrombosis	7,294 JPY (1,590 JPY)
ANA	Anastrozole 1 mg/day	Hot flash, arthritis, osteoporosis	11,301 JPY (4,312 JPY)
FUL	Fulvestrant 500 mg/4 weeks	Pain at injection site	101,584 JPY
EXE+mTOR	Exemestane 25 mg/day; Everolimus 10 mg/day	Interstitial pneumonitis, stomatitis	593,743 JPY (589,123 JPY)
LET+PAL	Letrozole 2.5 mg/day; Palbociclib 125 mg/day, 21 days	Bone marrow suppression, stomatitis	487,931 JPY (477,694 JPY)
FUL+PAL	Fulvestrant 500 mg/4 weeks; Palbociclib 125 mg/day, 21 days	Bone marrow suppression, stomatitis	575,350 JPY
HD-TOR	Toremifene 120 mg/day	Hot flash, thrombosis	25,368 JPY (13,079 JPY)

HD-TOR: high-dose toremifene.