Research Article
Breast Cancer Profile among Patients with a History of Chemoprevention
Table 1
Clinical characteristics.
| Variables | Primary (, 1%) | % | | Secondary (, 5%) | % | | Control (, 94%) | % |
| Median age (years) | 59 (46–76) | 0.39 | 66 (39–85) | <0.0001 | 59 (22–95) | Family history of breast cancer | | | | | | | | | Yes | 7 | 39 | 0.17 | 41 | 35 | 0.01 | 573 | 25 | No | 11 | 61 | 76 | 65 | 1722 | 75 | Genetic testing | | | | | | | | | Yes | 5 | 38 | 1.00 | 59 | 64 | <0.0001 | 633 | 40 | No | 8 | 62 | 33 | 36 | 944 | 60 | Not reported | 5 | — | 25 | — | 718 | — | BRCA 1,2 | | | | | | | | | Positive | 3 | 60 | 0.008 | 6 | 10 | 0.82 | 60 | 9 | Negative | 2 | 40 | 53 | 90 | 573 | 91 | Atypical hyperplasia (AH) | | | | | | | | | Yes | 8 | 44 | <0.0001 | 6 | 5 | 0.02 | 38 | 2 | No | 10 | 56 | 111 | 95 | 2257 | 98 | Lobular carcinoma in situ (LCIS) | | | | | | | | | Yes | 4 | 22 | <0.0001 | 1 | 1 | 1.00 | 21 | 1 | No | 14 | 78 | 116 | 99 | 2274 | 99 | Clinical stage of breast cancer | | | | | | | | | 0, I | 14 | 77 | 0.61 | 94 | 81 | 0.02 | 1605 | 70 | II, III, IV | 4 | 23 | 23 | 19 | 690 | 30 | Histology | | | | | | | | | DCIS (including DCIS w/microinv) | 8 | 44 | | 31 | 27 | | 530 | 23 | IDC | 8 | 44 | 0.15 | 67 | 57 | 0.64 | 1437 | 62 | ILC | 1 | 6 | 13 | 11 | 222 | 10 | Other invasive | 1 | 6 | | 6 | 5 | | 106 | 5 | Estrogen receptor | | | | | | | | | Positive | 16 | 89 | 1.00 | 83 | 73 | 0.004 | 1901 | 84 | Negative | 2 | 11 | 30 | 27 | 349 | 16 | Unknown | 0 | — | 4 | — | 45 | — | Progesterone receptor | | | | | | | | | Positive | 11 | 65 | 0.59 | 68 | 60 | 0.01 | 1615 | 72 | Negative | 6 | 35 | 45 | 40 | 632 | 28 | Unknown | 1 | — | 4 | — | 48 | — | HER2/neu | | | | | | | | | Positive | 1 | 10 | 1.00 | 12 | 14 | 0.42 | 220 | 13 | Negative | 9 | 90 | 72 | 86 | 1501 | 85 | Equivocal | 0 | 0 | 0 | 0 | 39 | 2 | Unknown/NA | 8 | — | 33 | — | 535 | — | Triple negative breast cancer | | | | | | | | | Yes | 1 | 6 | 1.00 | 12 | 10 | 0.28 | 170 | 7 | No | 17 | 94 | 105 | 90 | 2125 | 93 |
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Fisher’s Exact Test for primary versus nonchemoprevention groups. Fisher’s Exact Test for secondary versus nonchemoprevention groups.
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