Structural Brain Imaging Phenotypes of Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD) Found by Hierarchical Clustering

Figure 5

Results of voxel-wise -tests of gray matter distributions between cluster 5 and union of clusters 1-4 in Figure 1. Cluster 5 displayed more cortical atrophy than the union of clusters 1-4, especially in the frontal and temporal lobes. Moreover, the differences were strikingly unidirectional in all brain regions displaying marked differences. Coronal and sagittal views of the same figure are shown in Supplementary Results (Figures 5 b and 5 c). The FDR value corresponding to the threshold was 0.00135.