Structural Brain Imaging Phenotypes of Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD) Found by Hierarchical Clustering

<div>Top panel: radar plot of AD clusters. Cluster 8 consisted of, on average, strikingly young subjects, and the baseline ADAS score was the highest for all clusters. The role of APOE <svg height="8.55521pt" id="M35" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -8.34882 11.713 8.55521" width="11.713pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M387 375C387 402 357 448 257 448C172 448 82 404 82 326C82 289 108 255 156 241V239C85 223 23 181 23 116C23 39 89 -12 182 -12C265 -12 336 31 378 91L361 114C320 73 269 47 216 47C157 47 115 82 115 137C115 191 160 219 218 219C243 219 262 218 272 217L304 259L302 266C295 265 281 264 255 264C195 264 163 294 163 335C163 377 200 416 249 416C293 416 321 389 329 342C331 332 335 329 341 329C355 329 387 352 387 375Z"></path></g><g transform="matrix(.013,0,0,-0.013,5.331,0)"><path d="M456 178V225H360V632H320C217 496 115 347 20 206V178H280V106C280 40 276 34 189 27V0H445V27C364 34 360 39 360 106V178H456ZM280 225H82C149 335 214 431 278 520H280V225Z"></path></g></svg> was markedly elevated for cluster 2 as compared with other clusters. Bottom panel: table listing structural phenotypes for AD clusters with demographic and/or clinical features. Clusters 1 and 3 displayed the slowest average decline rate among the AD clusters in terms of the change in ADAS scores during the three-year follow-up. Color coding refers to structural similarity. The same color coding is used in subsequent, more detailed Figure <a href="../fig1/">1</a>.</div>

International Journal of Alzheimer’s Disease

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Figure 3

Figure 3: Structural Brain Imaging Phenotypes of Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD) Found by Hierarchical Clustering 