Research Article
Impaired Cerebral Vasomotor Reactivity in Alzheimer’s Disease
Table 1
Demographic, clinical, imaging, and blood sample characteristics of Alzheimer’s disease and healthy control participants.
| | Characteristic | Alzheimer’s disease (n=26) | Healthy controls (n=19)
|
| | (a) Demographic and clinical | | |
| | Age, median (range) | 78(67-93) | 78 (59-90) |
| | Gender, fem (%) | 21 (81%) | 15 (79%) |
| | Education years, median (range) | 3(0-15) | 6 (0-16) |
| | Diabetes mellitus, n (%) | 9(35%) | 4(21%) |
| | Hypertension, n (%) | 13(50%) | 8(42%) |
| | Dyslipidemia, n (%) | 5(19%) | 9(47%) |
| | Active smoking, n (%) | 6(23%) | 7(37%) |
| | MMSE, media (±SD) | 14.08(±5.80) | 27±(3.20) |
| | GDS, median (range) | 4 (0-9) | 3 (0-7) |
| | (b) MRI study and carotid ultrasound | | |
| | Leukoaraiosis >5mm | 6 (23%)
| 2 (11%)
|
| | Carotid plaques >30% | 11 (42%)
| 6 (32%)
|
| | Intima-media thickness | 0.902 (0.60 -2.0)
| 0.826 (0.6-1.10) |
| | (c) Blood samples | | |
| | Total cholesterol | 182.2 ± 36.4 | 197.6 ± 33.5
|
| | LDL | 111.6 ± 31.5
| 129.8 ± 32.3 |
| | HDL | 36.7 ± 11.5
| 38.2 ± 9.6 |
| | Triglycerides | 164.7 ± 100.4
| 147.5 ± 56.9
|
| | CRP | 3.7 ± 5.0
| 6.6 ± 9.1
|
| | Homocysteine | 10.3 ± 2.9
| 8.9 ± 3.6
|
|
|
MMSE: Mini-Mental State Examination; BMI: body mass index; GDS: Geriatric Depression Scale 15 item version; MRI: magnetic resonance imaging; LDL: low-density lipoprotein; HDL: high-density lipoprotein; CRP: C-reactive protein. Years. p < 0·05. |
