Early Contextual Fear Memory Deficits in a Double-Transgenic Amyloid-β Precursor Protein/Presenilin 2 Mouse Model of Alzheimer’s Disease

Figure 1

Spontaneous physical activities in PS2Tg2576 mice. The following 6 separate parameters of spontaneous behavior were evaluated in control wild-type mice (open column, ) and PS2Tg2576 mice (closed column, ) in the home-cage environment: (a) distance traveled, (b) walking, (c) rearing, (d) jumping, (e) hanging, and (f) body stretching. Ten mice of each genotype were used. The parameters were analyzed at ages of 3, 4, 6, and 10–12 months. At 6 months, PS2Tg2576 mice exhibited significantly higher spontaneous physical activities for distance traveled (a) and walking (b) ( and 0.025, resp.). At 10–12 months, PS2Tg2576 mice exhibited significantly higher spontaneous physical activities for distance traveled (a), walking (b), and rearing (c) (, 0.036, and 0.011, resp.). Data points represent the mean ± SEM. and versus the corresponding control group.

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