Drosophila Models of Tauopathies: What Have We Learned?

Table 1

Tau constructs available in Drosophila.

Constructs	Type	Origin
Drosophila  constructs
UAS-dTau	Wild-type	Mershin et al. 2004 [32]
UASp-dTau^A:mGFP6	Fusion	Doerflinger et al. 2003 [33]
UAS-dTau:1D4	Tagged form	Feuillette et al. 2010 [34]
Bovine constructs
UAS-bTau	Wild-type	Ito et al. 1997 [18]
bTau^1-382:GFP	Fusion	Micklem et al. 1997 [35]
UAS-bTau:GFP	Fusion	Murray et al. 1998 [19]
UAS-bTau:lacZ	Fusion	Callahan and Thomas 1994 [20]
Human 0N3R construct
UAS-hTau		Williams et al. 2000 [21]
Human 2N4R constructs
gl-hTau	Wild-type	Jackson et al. 2002 [7]
gl-hTau^P301L	FTDP17 mutation	Karsten et al. 2006 [22]
UAS-hTau		Chatterjee et al. 2009 [23]
gl-hTau^S2A (S262A/S356A)	Phospho-deficient	Chatterjee et al. 2009 [23]
UAS-hTau^S2A (S262A/S356A)	Phospho-deficient	Chatterjee et al. 2009 [23]
gl-hTau^S11A
(S46A/T50A/S199A/S202A/
S205A/T212A/ S214A/T231A/	Phospho-deficient	Chatterjee et al. 2009 [23]
S235A/S396A/S404A)
UAS-hTau^S11A
(S46A/T50A/S199A/S202A/
S205A/T212A/S214A/T231A/	Phospho-deficient	Chatterjee et al. 2009 [23]
S235A/S396A/S404A)
UAS-hTau:FLAG	Tagged form	Kosmidis et al. 2010 [24]
UAS-hTau^STA:FLAG  (S238A/T245A)	Tagged form Phospho-deficient	Kosmidis et al. 2010 [24]
Human 0N4R constructs
UAS-hTau	Wild-type	Wittmann et al. 2001 [6]
UAS-hTau^V337M	FTDP17 mutation	Wittmann et al. 2001 [6]
UAS-hTau^R406W	FTDP17 mutation	Wittmann et al. 2001 [6]
UAS-hTau^R406W  S2A (S262A/S356A)	FTDP17 mutation Phospho-deficient	Nishimura et al. 2004 [25]
UAS-hTau^R406W  S202A	FTDP17 mutation Phospho-deficient	Nishimura et al. 2004 [25]
UAS-hTau^T111A/T153A	Phospho-deficient	Steinhilb et al. 2007 MBC [26]
UAS-hTau^T175A/T181A	Phospho-deficient	Steinhilb et al. 2007 MBC [26]
UAS-hTau^T199A/T217A	Phospho-deficient	Steinhilb et al. 2007 MBC [26]
UAS-hTau^S202A/S205A	Phospho-deficient	Steinhilb et al. 2007 MBC [26]
UAS-hTau^T212A	Phospho-deficient	Steinhilb et al. 2007 MBC [26]
UAS-hTau^S214A	Phospho-deficient	Steinhilb et al. 2007 MBC [26]
UAS-hTau^T231A/S235A	Phospho-deficient	Steinhilb et al. 2007 MBC [26]
UAS-hTau^S262A	Phospho-deficient	Iijima-Ando et al. 2010 [28]
UAS-hTau^S396A/S404A	Phospho-deficient	Steinhilb et al. 2007 MBC [26]
UAS-hTau^S422A	Phospho-deficient	Steinhilb et al. 2007 MBC [26]
UAS-hTau^AP5
(S202A/S205A/T212A/	Phospho-deficient	Steinhilb et al. 2007 MBC [26]
T231A/S235A)
UAS-hTau^AP
(T111A/T153A/T175A/T181A/
S199A/S202A/S205A/T212A/	Phospho-deficient	Steinhilb et al. 2007 JNR [26]
S214A/T217A/T231A/S235A/
S396A/S404A/S422A)
UAS-hTau^E14
(T111E/T153E/T175E/T181E/
S199E/S202E/S205E/ T212E/	Phosphomimetic	Khurana et al. 2006 [29]
T217E/T231E/S235E/S396E/
S404E/S422E)
UAS-hTau^K44Q/R230Q	Calpain-resistant	Reinecke et al. 2011 [30]
UAS-hTau^44-230	Calpain 17kDA proteolytic fragment	Reinecke et al. 2011 [30]
UAST-hTau^1-421	C-terminally truncated Tau	Khurana et al. 2010 [31]