Choline Modulation of the Aβ P1-40 Channel Reconstituted into a Model Lipid Membrane

Figure 6

AβP1-40 channel mean conductance and frequency in POPC:Ch PLM. (a) Λ_𝑐±SE and (b) frequency ± SD of AβP1-40 channel without and with choline (5 ×10⁻¹¹ M) (added to the cis or trans side of the chamber) in POPC:Ch (65 : 35, w/w) PLM. The minimum and maximum number of channels considered (N) out of a total number of channels considered (𝑁_𝑡) was: AβP1-40, 761<𝑁<1283, 𝑁_𝑡=2928; AβP1-40 + choline cis, 449<𝑁<1320, 𝑁_𝑡=2305; AβP1-40 + choline trans, 170<𝑁<624, 𝑁_𝑡=1269.

(a)

(b)