Applying New Research Criteria for Diagnosis of Early Alzheimer's Disease: Sex and Intelligence Matter
Table 1
Characterization of the study sample: ranges, mean, and standard deviations in brackets. MMSE: Mini-Mental Status Examination; WST: German Vocabulary Test (Wortschatztest) as a measure of Intelligence; CSF: cerebrospinal fluid; Low IQ (); High IQ ().
Low IQ ()
High IQ ()
Male
Female
Male
Female
20
15
18
15
Age
57–80
58–85
56–81
58–85
(68.0 7.0)
(71.1 8.0)
(70.0 8.6)
(68.7 8.6)
MMSE
22–30
22–29
24–30
22–30
(26.3 2.3)
(25.7 2.2)
(27.8 1.7)*
(26.1 2.4)
WST
17–30
12–30
31–39
31–39
(23.8 4.0)
(24.5 4.9)
(34.4 2.5)
(33.7 2.1)
CSF tau
100–1658
74–1242
75–1428
200–1500
(463 387)
(494 298)
(431 366)
(770 413)§
CSF Abeta
109–1140
262–1380
100–1351
221–1153
(624 310)
(523 287)
(700 377)
(533 275)
Number of Abnormal biomarkers#
One:
One:
One:
One:
Two:
Two:
Two:
Two:
Three:
Three:
Three:
Three:
*: significant difference to high IQ females and low IQ males; §: significant difference to high IQ males; #: CSF tau, CSF Abeta, MRI.
