Determination of Crizotinib in Mouse Tissues by LC-MS/MS and Its Application to a Tissue Distribution Study

Figure 4

Typical MRM chromatograms of crizotinib (I) and apatinib (II, IS). (a) Blank liver homogenate sample; (b) liver tissue sample obtained from a mouse at 8 h after intragastric administration of 500 mg/kg crizotinib; (c) blank small intestine homogenate sample; and (d) small intestine tissue sample obtained from a mouse at 8 h after intragastric administration of 500 mg/kg crizotinib.

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(b)

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