Cholera Infection Risks and Cholera Vaccine Safety in Pregnancy

Table 5

Cholera vaccination during pregnancy results.

Author	Country	Effect of cholera vaccine on pregnancy
Hashim et al. [14]	Korea	Both groups had approximately the same probability of spontaneous abortions, fetus abnormalities, or deaths
Ciglenecki et al. [18]	Haiti	Women who were previously exposed to cholera had a higher chance of pregnancy loss and fetal abnormality compared to healthy women
Grout et al. [20]	USA	(i) 3.7% (95% CI 2.7–4.8) of miscarriages were observed among vaccinated women compared to 2.6% among nonvaccinated ones; (ii) Vaccinated women were at lower risk of malformation frequency 0.6% (0.1-1.0) compared to nonvaccinated women 1.2% (0.0-2.5); (iii) Even if there was a correlation between the exposure of the vaccine and the risk of miscarriage or fetal deformity, it is negligible; (iv) The OCV is safe for pregnant women and does not offer any risk to the fetus; (v) A negative relationship was seen between the Shanchol vaccine exposure and fetal complications
Ali et al. [13]	USA	Compared to 835 nonvaccinated women, 835 vaccinated women were at an equal risk of stillbirth, spontaneous abortion, birth defects, or fetal mortality
Khan et al. [12]	Bangladesh	There is no increased risk on the fetuses of OCV-exposed pregnant women
WHO [1]	Worldwide	Vaccinating all pregnant women against the cholera vaccine is effective and safe