Abstract
Aims. To investigate the possible association
of human papillomavirus (HPV) with endometrial hyperplasias and
neoplasia. Does HPV play any role in the initiation or
prognosis of endometrial adenocarcinomas?
Methods. Twenty-five endometrial adenocarcinomas
of the endometrioid cell type, with and without squamous
differentiation, and twenty-four endometrial hyperplasias of various
forms (simple, complex, and atypical) were analyzed for the
presence of type 16 and 18 HPV by the polymerase chain
reaction (PCR). The results were related to histopathological
features of the tumour, and the patients' age, and
prognosis. Results. Six of 25 endometrial
adenocarcinomas were HPV 16-positive
(