Clinical Study
Validation of Hepascore as a Predictor of Liver Fibrosis in Patients with Chronic Hepatitis C Infection
Table 3
Comparison of cut-off points, sensitivity, specificity, PPV, and NPV in different studies.
| | Adams et al. [12] | Leroy et al. [16] | Halfon et al. [17] | Becker et al. [1] | Guechot et al. [14] | This study |
| Patients number | 104 | 180 | 356 | 391 | 512 | 80 | F0/F1/F2/F3/F4 (%) | 16/27/34/7/16 | 8/41/22/14/14 | 4/55/26/11/4 | 16/34/15/16/19 | 7/45/18/15/15 | 15/31/25/8/20 |
| For significant fibrosis | | Cut-off | 0.5 | 0.5 | 0.32 | 0.55 | 0.5 | 0.34 | Sensitivity | 63% | 54% | 77% | 82% | 77% | 67% | Specificity | 89% | 84% | 63% | 65% | 70% | 56% | Positive predictive value | / | 78% | 59% | 70% | 71% | 64% | Negative predictive value | / | 64% | 80% | 78% | 77% | 56% |
| For sever fibrosis | | Cut-off | / | 0.84 | 0.53 | 0.8 | 0.6 | 0.61 | Sensitivity | / | 47% | 78% | / | 80% | 82% | Specificity | / | 90% | 72% | 77% | 70% | 86% | Positive predictive value | / | 65% | 32% | 62% | 54% | 70% | Negative predictive value | / | 81% | 95% | / | 89% | 92% |
| For cirrhosis | | Cut-off | 0.84 | / | 0.61 | / | 0.75 | 0.84 | Sensitivity | 71% | / | 92% | / | 86% | 100 | Specificity | 89% | / | 72% | / | 74% | 97% | Positive predictive value | / | / | 11% | / | 37% | 89% | Negative predictive value | | / | 100% | / | 97% | 100 |
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