Autoimmune Hepatitis: A Review of Current Diagnosis and Treatment

Table 1

HLA associations in autoimmune hepatitis.

HLA Association (Reference)	Ethnicity/Comments	AIH Type	Number of patients studied	Patients	Controls
HLA-DRB1∗0401 [15]	(i) European and North American Increases susceptibility to AIH Type I in Caucasians; (ii) HLA-DR3 associated with younger age at presentation, diminished response to therapy and more frequent liver failure requiring liver transplantation as compared to HLA-DR4	I	119	45%	23%
HLA-DRB3∗0101 [15]	European and North American	I	119	58%	25%
HLA-DRB1∗0404 [16]	Mexican	I	30	36.7%	7.4%
HLA-DRB1∗0405 [17]	Japanese	—	49	67.3%	29.6%
HLA-DRB1∗07 [18]	Brazil	II	28	68%	20%
HLA-B14 [19]	Germany	II	19	26%	4%