Research Article
The Association between Platelet Glycocalicin and High Microsatellite Instability in Colorectal Cancer
Table 2
Clinicopathological characteristics of the CRC patients according to microsatellite instability status.
| Variables | Total | MSI-H | MSS | value |
| Number | 430 | 64 | 366 | | Age (years) | 59.4 ± 10.0 | 56.4 ± 11.8 | 59.9 ± 9.6 | 0.029 | Gender (female, %) | 181 (42.1) | 33 (51.6) | 148 (40.4) | 0.096 | BMI (kg/m2) | 23.4 ± 3.2 | 24.5 ± 3.3 | 23.2 ± 3.2 | 0.004 | Current smoker (%) | 183 (42.6) | 25 (39.1) | 158 (43.2) | 0.540 | Drinker (, %) | 139 (32.3) | 17 (26.6) | 122 (33.3) | 0.285 | Creatinine (μmol/L) | 81.1 ± 18.6 | 80.9 ± 19.7 | 81.1 ± 18.4 | 0.929 | CEA (ng/mL) | 3.14 (1.57-7.98) | 3.14 (1.57-7.98) | 4.86 (2.15-12.12) | 0.030 | WBC (×109/L) | 7.09 ± 2.44 | 8.07 ± 2.98 | 6.92 ± 2.30 | 0.004 | Hemoglobin (g/L) | 132.9 ± 23.4 | 124.6 ± 27.3 | 134.3 ± 22.4 | 0.009 | Platelet count (×109/L) | 269.7 ± 87.8 | 286.2 ± 112.6 | 266.8 ± 82.6 | 0.103 | Glycocalicin (ng/mL) | 26.5 ± 6.0 | 22.6 ± 6.3 | 27.2 ± 5.6 | < 0.001 | Tumor location (%) | | | | < 0.001 | Proximal | 157 (36.5) | 38 (59.4) | 119 (32.5) | | Distal | 273 (63.5) | 26 (40.6) | 247 (67.5) | | Tumor size (cm, %) | | | | 0.011 | <5.0 | 282 (65.6) | 33 (51.6) | 249 (68.0) | | ≥5.0 | 148 (34.4) | 31 (48.4) | 117 (32.0) | | Histological grade (%) | | | | 0.419 | Well/moderately differentiated | 307 (71.4) | 43(67.2) | 264 (72.1) | | Poorly differentiated | 123 (28.6) | 21 (32.8) | 102 (27.9) | | Histological type (%) | | | | 0.007 | Non-mucinous | 359 (83.5) | 46 (71.9) | 313 (85.5) | | Mucinous | 71 (16.5) | 18 (28.1) | 53 (14.5) | | Lymphatic invasion (%) | | | | 0.030 | Absent | 331 (77.0) | 56 (87.5) | 275 (75.1) | | Present | 99 (23.0) | 8 (12.5) | 91 (24.9) | | Perineural invasion (%) | | | | 0.527 | Absent | 365 (84.9) | 56 (87.5) | 309 (84.4) | | Present | 65 (15.1) | 8 (12.5) | 57 (15.6) | | T classification (%) | | | | 0.811 | T1+T2 | 63 (14.7) | 10 (15.6) | 53 (14.5) | | T3+T4 | 367 (85.3) | 54 (84.4) | 313 (85.5) | | Lymph node metastasis (%) | | | | 0.010 | Absence | 267 (62.1) | 49 (76.6) | 218 (59.6) | | Presence | 163 (37.9) | 15 (23.4) | 148 (40.4) | | Distant metastasis (%) | | | | 0.713 | Absence | 382 (88.8) | 56 (87.5) | 326 (89.1) | | Presence | 48 (11.2) | 8 (12.5) | 40 (10.9) | | Stage (%) | | | | 0.003 | I-II | 258 (60.0) | 49 (76.6) | 209 (57.1) | | III-IV | 172 (40.0) | 15 (23.4) | 157 (42.9) | |
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Data are presented as means (standard deviation), median (interquartile range), or number (percentage). Abbreviations see Table 1. |