Research Article

The Association between Platelet Glycocalicin and High Microsatellite Instability in Colorectal Cancer

Table 2

Clinicopathological characteristics of the CRC patients according to microsatellite instability status.

VariablesTotalMSI-HMSS value

Number43064366
Age (years)59.4 ± 10.056.4 ± 11.859.9 ± 9.60.029
Gender (female, %)181 (42.1)33 (51.6)148 (40.4)0.096
BMI (kg/m2)23.4 ± 3.224.5 ± 3.323.2 ± 3.20.004
Current smoker (%)183 (42.6)25 (39.1)158 (43.2)0.540
Drinker (, %)139 (32.3)17 (26.6)122 (33.3)0.285
Creatinine (μmol/L)81.1 ± 18.680.9 ± 19.781.1 ± 18.40.929
CEA (ng/mL)3.14 (1.57-7.98)3.14 (1.57-7.98)4.86 (2.15-12.12)0.030
WBC (×109/L)7.09 ± 2.448.07 ± 2.986.92 ± 2.300.004
Hemoglobin (g/L)132.9 ± 23.4124.6 ± 27.3134.3 ± 22.40.009
Platelet count (×109/L)269.7 ± 87.8286.2 ± 112.6266.8 ± 82.60.103
Glycocalicin (ng/mL)26.5 ± 6.022.6 ± 6.327.2 ± 5.6< 0.001
Tumor location (%)< 0.001
 Proximal157 (36.5)38 (59.4)119 (32.5)
 Distal273 (63.5)26 (40.6)247 (67.5)
Tumor size (cm, %)0.011
 <5.0282 (65.6)33 (51.6)249 (68.0)
 ≥5.0148 (34.4)31 (48.4)117 (32.0)
Histological grade (%)0.419
 Well/moderately differentiated307 (71.4)43(67.2)264 (72.1)
 Poorly differentiated123 (28.6)21 (32.8)102 (27.9)
Histological type (%)0.007
 Non-mucinous359 (83.5)46 (71.9)313 (85.5)
 Mucinous71 (16.5)18 (28.1)53 (14.5)
Lymphatic invasion (%)0.030
 Absent331 (77.0)56 (87.5)275 (75.1)
 Present99 (23.0)8 (12.5)91 (24.9)
Perineural invasion (%)0.527
 Absent365 (84.9)56 (87.5)309 (84.4)
 Present65 (15.1)8 (12.5)57 (15.6)
T classification (%)0.811
 T1+T263 (14.7)10 (15.6)53 (14.5)
 T3+T4367 (85.3)54 (84.4)313 (85.5)
Lymph node metastasis (%)0.010
 Absence267 (62.1)49 (76.6)218 (59.6)
 Presence163 (37.9)15 (23.4)148 (40.4)
Distant metastasis (%)0.713
 Absence382 (88.8)56 (87.5)326 (89.1)
 Presence48 (11.2)8 (12.5)40 (10.9)
Stage (%)0.003
 I-II258 (60.0)49 (76.6)209 (57.1)
 III-IV172 (40.0)15 (23.4)157 (42.9)

Data are presented as means (standard deviation), median (interquartile range), or number (percentage). Abbreviations see Table 1.