The Association between Platelet Glycocalicin and High Microsatellite Instability in Colorectal Cancer
Table 1
Baseline characteristics of CRC patients according to glycocalicin levels.
Variables
Total
Glycocalicin ≤20.5 ng/mL
Glycocalicin >20.5 ng/mL
value
Age (years)
0.575
≤65
309 (71.9)
42 (75.0)
267 (71.4)
>65
121 (28.1)
14 (25.0)
107 (28.6)
Gender (%)
0.581
Male
245 (57.0)
30 (53.6)
215 (57.5)
Female
185 (43.0)
26 (46.4)
159 (42.5)
BMI (kg/m2)
23.4 ± 3.2
23.9 ± 3.6
23.3 ± 3.2
0.199
Current smoker (%)
0.809
Yes
183 (42.6)
23 (41.1)
160 (42.8)
No
247 (57.4)
33 (58.9)
214 (57.2)
Drinker (%)
0.375
Yes
139 (32.3)
21 (37.5)
118 (31.6)
No
291 (67.7)
35 (62.5)
256 (68.4)
WBC (×109/L)
7.09 ± 2.44
7.23 ± 2.43
7.07 ± 2.45
0.657
Hemoglobin (g/L)
132.9 ± 23.4
128.0 ± 27.0
133.6 ± 22.8
0.138
Platelet count (×109/L)
269.7 ± 87.8
278.5 ± 96.1
268.3 ± 86.6
0.417
Creatinine (μmol/L)
81.1 ± 18.6
80.4 ± 12.5
81.2 ± 19.3
0.790
CEA (ng/mL)
4.37 (2.03-11.31)
3.49 (1.86-12.04)
4.52 (2.12-11.07)
0.499
Tumor size (cm)
0.208
<5.0
278 (64.7)
32 (57.1)
246 (65.8)
≥5.0
152 (35.3)
24 (42.9)
128 (34.2)
Tumor location (%)
0.051
Proximal
157 (36.5)
27 (48.2)
130 (34.8)
Distal
273 (63.5)
29 (51.8)
244 (65.2)
Histological type (%)
0.756
Non-mucinous
307 (71.4)
39 (69.6)
268-71.7
Mucinous
123 (28.6)
17 (30.4)
106 (28.3)
Histological grade (%)
0.147
Well/moderately differentiated
359 (83.5)
43 (76.8)
316 (84.5)
Poorly differentiated
71 (16.5)
13 (23.2)
58 (15.5)
Lymphatic invasion (%)
0.185
Absent
331 (77.0)
47 (83.9)
284 (75.9)
Present
99 (23.0)
9 (16.1)
90 (24.1)
Perineural invasion (%)
0.545
Absent
365 (84.9)
48 (85.7)
317 (84.8)
Present
65 (15.1)
8 (14.3)
57 (15.2)
T classification (%)
0.372
T1+T2
63 (14.7)
6 (10.7)
57 (15.2)
T3+T4
367 (85.3)
50 (89.3)
317 (84.8)
Lymph node metastasis (%)
0.511
Absence
267 (62.1)
37 (66.1)
230 (61.5)
Presence
163 (37.9)
19 (33.9)
144 (38.5)
Distant metastasis (%)
0.426
Absence
382 (88.8)
48 (85.7)
334 (89.3)
Presence
48 (11.2)
8 (14.3)
40 (10.7)
Stage (%)
0.682
I-II
258 (60.0)
35 (62.5)
223 (59.6)
III-IV
172 (40.0)
21 (37.5)
151 (40.4)
MSI status (%)
< 0.001
MSS
366 (85.1)
27 (48.2)
339 (90.6)
MSI-H
64 (14.9)
29 (51.8)
35 (9.4)
Data are presented as means (standard deviation), median (interquartile range), or number (percentage). BMI: body mass index; WBC: white blood cells; CEA: carcinoembryonic antigen; MSS: microsatellite stable; MSI: microsatellite instability; MSI-H: high MSI.
