Research Article

Scientific Evidence of Chinese Herbal Medicine (Gegen Qinlian Decoction) in the Treatment of Ulcerative Colitis

Table 2

Characteristics of the included reviews.

Author, yearCountrySampleTreatment interventionControl interventionQuality assessmentDiagnostic criteriaOutcomesConclusion summary

Tang et al. [14], 2021China15 (1323)CMCochrane criteriaConsensus on the diagnosis and treatment specifications for inflammatory bowel disease in China (2007)①, ②, ⑦Compared with WMs, GQD or combined with sulfasalazine appeared to be more effective for UC. This finding provides a new therapeutic option for the treatment of UC. Nevertheless, due to the limitations of the included studies, further studies with higher quality and more rigorous design are needed to confirm the results of this study.
Xing [15], 2021China10 (861)CMCochrane criteriaConsensus on the diagnosis and treatment specifications for inflammatory bowel disease in China (2007)⑤, ⑥GQD combined with CM can more effectively improve the effective rate of patients with UC and improve the level of serum inflammatory factors. However, further implementation of larger and higher quality clinical trials is necessary to verify the conclusion.
Qin et al. [16], 2019China5 (381)CMCochrane criteriaConsensus on the treatment of ulcerative colitis in Chinese medicine (2010)①, ③, ⑦GQD combined with CM can more effectively improve the effective rate of patients with UC. Nevertheless, due to the limitations of this study, high-quality studies are still needed to further strengthen the conclusions of this study.
Fan [17], 2019China22 (2028)CMCochrane criteriaThird European evidence-based consensus on diagnosis and management of UC①, ②, ④, ⑦The combination of GQD with CM has potential benefits in the treatment of UC. However, due to the poor methodological quality of the included studies, there is insufficient evidence to draw firm conclusions to support the role of GQD for UC. Large-sample studies with more rigorous designs should be conducted to further establish clinical evidence.

①: effective rate; ②: recurrence rate; ③: mucosal improvement; ④: UCEIS score; ⑤: level of TNF-α; ⑥: level of IL-6; ⑦: adverse events.