ZNF521 Is Correlated with Tumor Immune Cell Infiltration and Act as a Valuable Prognostic Biomarker in Gastric Cancer

Table 2

The correlation of ZNF521 mRNA expression and clinical prognosis in gastric cancer with different clinicopathological factors by Kaplan–Meier plotter.

Clinicopathological characteristics	N	OS	-value	N	FP	-value	N	PPS	-value
		HR			HR			HR
		Gender
Female	236	2.41 (1.47–3.96)	0.00031	201	2.24 (1.38–3.63)	0.0008	149	2.61 (1.49–4.59)	0.00053
Male	544	1.71 (1.27–2.31)	0.00036	437	1.67 (1.24–2.23)	0.00056	348	1.86 (1.32–2.63)	3.00 × 10^−4
Stage
1	67	1.76 (0.57–5.42)	0.32	60	1.68 (0.54–5.2)	0.36	31
2	140	2.18 (1.13–4.19)	0.017	131	1.99 (1.06–3.73)	0.029	105	3.33 (1.65–6.71)	0.00037
3	205	1.44 (0.98–2.13)	0.064	186	1.63 (1.12–2.39)	0.011	142	1.6 (1.02–2.5)	0.037
4	148	1.85 (1.24–2.75)	0.0022	141	1.44 (0.98–2.11)	0.064	104	1.84 (1.17–2.91)	0.0076
Stage T
1	14			14			3
2	241	1.9 (1.24–2.9)	0.0025	239	1.71 (1.13–2.58)	0.0099	196	2.29 (1.46–3.59)	0.00019
3	204	1.22 (0.83–1.78)	0.37	204	0.81 (0.56–1.18)	0.27	150	1.27 (0.85–1.89)	0.25
4	38	3.38 (1.37–8.32)	0.0051	39	2.7 (1.19–6.14)	0.014	29
Stage N
0	74	2.15 (0.93–4.98)	0.068	72	2.05 (0.89–4.74)	0.086	41	4.09 (1.25–13.37)	0.012
1	225	2.28 (1.46–3.55)	2.00 × 10^−4	222	2 (1.32–3.03)	0.00082	169	1.98 (1.47–2.66)	4.40 × 10^−6
2	121	1.53 (0.95–2.47)	0.08	125	1.6 (1.03–2.48)	0.036	105	2.68 (1.64–4.37)	4.10 × 10^−5
3	76	2.05 (1.16–3.63)	0.012	76	1.8 (1.01–3.19)	0.046	63	1.55 (0.94–2.53)	0.081
1 + 2 + 3	422	1.89 (1.43–2.49)	4.30 × 10^−6	423	1.77 (1.36–2.3)	1.40 × 10^−5	437	1.91 (1.07–3.42)	0.026
Stage M
0	444	1.84 (1.38–2.46)	2.40 × 10^−5	443	1.77 (1.34–2.32)	3.80 × 10^−5	342	2.03 (1.5–2.74)	2.50 × 10^−6
1	56	1.9 (1.05–3.44)	0.031	56	1.54 (0.85–2.79)	0.15	36	2.65 (1–7.06)	0.043
Lauren classification
Intestinal	320	1.74 (1.21–2.5)	0.0024	263	1.7 (1.2–2.42)	0.0026	192	1.75 (1.16–2.63)	0.007
Diffuse	241	1.71 (1.15–2.54)	0.0079	231	1.86 (1.24–2.8)	0.0024	176	1.89 (1.29–2.77)	0.00095
Mixed	32	3.32 (1.09–10.12)	0.026	28	1.9(0.54–6.73)	0.31	16
Differentiation
Poor	165	1.22 (0.75–1.97)	0.42	121	1.23 (0.73–2.05)	0.44	49	1.31 (0.69–2.48)	0.41
Moderate	67	1.55 (0.79–3.03)	0.19	67	1.9 (0.99–3.65)	0.05	24	0.42 (0.16–1.16)	0.086
Well	32			5			0

Bold values indicate that statistical significance was set at P < 0.05.