Explore the Mechanism of Astragalus mongholicus Bunge against Nonalcoholic Fatty Liver Disease Based on Network Pharmacology and Experimental Verification

Figure 10

Quercetin exerts an anti-NAFLD effect by regulating the AMPK/MAPK/TNF-α and AMPK/ACC/CPT1α signaling pathways to inhibit inflammation and enhance fatty acid β-oxidation. Activation of AMPK by quercetin leads to downregulation of MAPK signaling pathways and decreases the expression of TNF-α, which may contribute to relieve inflammation. In addition, phospho-AMPK phosphorylates ACC, the rate-limiting enzyme of de novo lipogenesis. This decrease in ACC activity limits malonyl CoA production, relieving the inhibition of CPT-1α activity and enhancing fatty acid β-oxidation.