Research Article
Identifying the Mechanism of Polygoni Cuspidati Rhizoma et Radix in Treating Acute Liver Failure Based on Network Pharmacology and Molecular Docking
Table 3
Core targets of PCRR in the treatment of ALF and the topological parameters.
| Uniport ID | Gene symbol | Degree | Betweenness | Closeness |
| P04637 | TP53 | 40 | 0.11 | 0.49 | P31749 | AKT1 | 39 | 0.11 | 0.49 | P05412 | JUN | 36 | 0.09 | 0.50 | P07900 | HSP90AA1 | 35 | 0.08 | 0.48 | P28482 | MAPK1 | 34 | 0.12 | 0.50 | Q04206 | RELA | 33 | 0.06 | 0.49 | P01375 | TNF | 28 | 0.06 | 0.46 | P03372 | ESR1 | 26 | 0.04 | 0.46 | P05231 | IL6 | 25 | 0.04 | 0.44 | P01106 | MYC | 24 | 0.03 | 0.46 | Q16539 | MAPK14 | 23 | 0.02 | 0.46 | P01100 | FOS | 23 | 0.04 | 0.46 | P06400 | RB1 | 22 | 0.02 | 0.45 | P38936 | CDKN1A | 21 | 0.01 | 0.43 | P00533 | EGFR | 21 | 0.03 | 0.44 |
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PCRR: Polygoni Cuspidati Rhizoma et Radix; ALF: acute liver failure.
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