Risk Factors for Worsening of Bone Loss in Patients Newly Diagnosed with Inflammatory Bowel Disease

Table 4

Univariate and multivariate analysis of risk factors for bone loss in patients newly diagnosed with inflammatory bowel disease.

	IBD			CD			UC
	Univariate	Multivariate		Univariate	Multivariate		Univariate	Multivariate
			OR (95% CI)			OR (95% CI)			OR (95% CI)
Disease type	0.658			NA	NA		NA	NA
Age at diagnosis (year)	0.023	0.037	2.320 (1.155–4.854)	0.056	0.23	1.003 (0.703–1.432)	0.036	0.043	4.896 (1.223–18.607)
Sex	0.382			0.689			0.244
BMI (kg/m^2)	<0.001	0.005	0.373 (0.206–0.692)	0.004	0.022	0.573 (0.348–0.862)	<0.001	0.002	0.445 (0.263–0.765)
Smoking	0.102			0.236			0.754
Alcohol intake	0.512			0.059	0.836	0.974 (0.760–1.249)	0.343
Symptom duration (months)	0.879			0.939			0.623
Menopause	0.760			0.865			0.136
Hospitalizations	0.389			0.454			0.613
Intestinal surgery history	0.864			0.882			0.471
Body composition
FMI (kg/height m^2)	0.056	0.408	0.902 (0.653–1.247)	0.209			0.142
ASMI (kg/height m^2)	0.127			0.354			0.481
Biochemical characteristics
CRP (mg/L)	0.778			0.403			0.914
Albumin (g/L)	0.403			0.318			0.632
Calcium (mmol/L)	0.133	0.673		0.219			0.345
Phosphorus (mmol/L)	0.089	0.018	0.562 (0.274–0.831)	0.026	0.003	0.456 (0.241–0.864)	0.131	0.654	0.872 (0.585–1.310)

Abbreviations: IBD: inflammatory bowel disease; CD: Crohn’s disease; UC: ulcerative colitis; BMI: body mass index; FMI: fat mass index; ASMI: appendicular skeletal muscle index; CRP: C-reactive protein; OR: odds ratio; CI: confidence interval.