Effect of Neuroligin1 and Neurexin1 on the Colonic Motility in a Mouse Model of Neuronal Intestinal Dysplasia

<div>Decrease of the upregulated expressions of NL1 and NX1 and correlated recovery of the impaired colonic motility after intervention. Huperzine A was given to the Tlx2<sup>-/-</sup> mice by intragastric gavage and retention-enema for 8 weeks. Western blots (a–c) show that the upregulated expressions of protein NL1 and NX1 decreased after intervention in groups HIG and HRE. qPCR assay (d, e) confirmed the decreased expressions of NL1 and NX1. 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Gastroenterology Research and Practice

fig4

Figure 4

Figure 4: Effect of Neuroligin1 and Neurexin1 on the Colonic Motility in a Mouse Model of Neuronal Intestinal Dysplasia 