Research Article
Effect of Neuroligin1 and Neurexin1 on the Colonic Motility in a Mouse Model of Neuronal Intestinal Dysplasia
Figure 3
Increase of glutamatergic synapses in Tlx2+/- mice: immunohistochemistry staining (a) showed that glutamatergic synapses marked by NR1 and VGLUT1 existed and mainly concentrated in the myenteric plexus of the distal colon of mice; Western blot (b–d) and qPCR (e, f) indicated that expressions of NR1 and VGLUT1 in the Tlx2-/- mice were higher compared to those in the WT and Tlx2+/- mice, which indicated the increase of glutamatergic synapses in the Tlx2-/- mice colon ( versus WT, # versus Tlx2+/-).
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