Clinicopathological Features and Prognostic Implication of Gastric Carcinoma with Lymphoid Stroma

Table 3

Clinicopathological significances of gastric carcinoma with lymphoid stroma.

	Number of subsets	Fixed effect (95% CI)	Heterogeneity test ( value)	Random effect (95% CI)	Egger’s test ( value)	Meta-regression test ( value)
Age
GCLS	13	57.892 [57.293, 58.491]	<0.001	58.182 [56.857, 59.507]	0.412	0.152
Non-GCLS	11	58.252 [58.059, 58.445]	<0.001	59.864 [58.410, 61.318]	0.164
Male ratio
GCLS	26	0.794 [0.772, 0.815]	<0.001	0.765 [0.712, 0.811]	0.064	0.052
Non-GCLS	18	0.686 [0.678, 0.694]	<0.001	0.709 [0.665, 0.751]	0.333
Size (cm)
GCLS	7	2.763 [2.618, 2.908]	<0.001	3.275 [2.521, 4.029]	0.181	0.032
Non-GCLS	7	2.908 [2.865, 2.951]	<0.001	4.636 [3.786, 5.486]	0.018
Lauren’s classification, diffuse type
GCLS	10	0.554 [0.504, 0.602]	<0.001	0.577 [0.437, 0.705]	0.512	0.036
Non-GCLS	8	0.444 [0.433, 0.455]	<0.001	0.455 [0.397, 0.514]	0.949
Tumor differentiation, poorly
GCLS	8	0.407 [0.369, 0.446]	<0.001	0.710 [0.474, 0.870]	0.070	0.376
Non-GCLS6	6	0.618 [0.605, 0.630]	0.009	0.610 [0.574, 0.645]	0.859
Tumor location, proximal 1/3
GCLS	15	0.280 [0.254, 0.308]	<0.001	0.249 [0.190, 0.319]	0.223	<0.001
Non-GCLS	14	0.132 [0.126, 0.137]	<0.001	0.148 [0.123, 0.177]	0.375
Lymphatic invasion
GCLS	6	0.330 [0.253, 0.417]	<0.001	0.259 [0.113, 0.490]	0.369	0.024
Non-GCLS	7	0.381 [0.368, 0.395]	<0.001	0.516 [0.405, 0.625]	0.116
Vascular invasion
GCLS	7	0.257 [0.193, 0.334]	<0.001	0.146 [0.049, 0.361]	0.336	0.666
Non-GCLS	8	0.127 [0.117, 0.137]	<0.001	0.214 [0.120, 0.353]	0.099
Perineural invasion
GCLS	13	0.150 [0.122, 0.183]	<0.001	0.104 [0.056, 0.184]	0.170	0.335
Non-GCLS	9	0.129 [0.122, 0.137]	<0.001	0.158 [0.081, 0.284]	0.977
pT stage, pT1/T2
GCLS	14	0.624 [0.587, 0.660]	<0.001	0.592 [0.472, 0.702]	0.559	0.102
Non-GCLS	12	0.728 [0.716, 0.740]	<0.001	0.428 [0.301, 0.565]	0.005
Lymph node metastasis
GCLS	20	0.351 [0.322, 0.381]	<0.001	0.308 [0.217, 0.417]	0.368	0.100
Non-GCLS	15	0.324 [0.314, 0.333]	<0.001	0.462 [0.322, 0.608]	0.486
Distant metastasis
GCLS	2	0.197 [0.057, 0.499]	<0.001	0.197 [0.057, 0.499]	—	—
pTNM stage, I/II
GCLS	13	0.696 [0.659, 0.731]	<0.001	0.750 [0.599, 0.858]	0.428	0.042
Non-GCLS	11	0.685 [0.673, 0.697]	<0.001	0.500 [0.317, 0.683]	0.240

CI, confidence interval; GCLS, gastric carcinoma with lymphoid stroma.