Treatment Adherence in Inflammatory Bowel Disease Patients from Argentina: A Multicenter Study

Table 4

Univariate and multivariate analysis of variables associated with inadequate adherence to thiopurines.

	Inadequate adherence group ()	Adequate adherence group ()	Univariate analysis		Multivariate analysis
			OR (CI95%)		OR (CI95%)
Gender (% male)	46.32 (44/95)	39.72 (56/141)	1.31 (0.77-2.22)	0.3
Age, median (IQR)	37 (22/71)	36 (21/70)	N/A	0.8
Years since diagnosis, median (IQR)	6 (1-37)	6 (1-31)	N/A	0.8
Primary level of education (%)	9.47 (9/95)	6.38 (9/141)	1.53 (0.58-4.03)	0.4
Lives alone (%)	20 (19/95)	17.02 (24/141)	1.22 (0.62-2.38)	0.5
Disability certificate (%)	31.58 (30/95)	22 (31/141)	1.63 (0.9-2.96)	0.09
Health coverage (% union-funded health insurance)	49.47 (47/95)	50.35 (71/141)	0.96 (0.57-1.62)	0.9
Smoking (%)	18.95 (18/95)	5.67 (8/141)	3.88 (1.57-9.56)	0.01	3.75 (1.53–9.17)	0.004
History of IBD-related surgery (%)	8.42 (8/95)	10.64 (15/141)	0.77 (0.31-1.9)	0.5
History of hospitalization due to IBD (%)	46.32 (44/95)	55.32 (78/141)	0.69 (0.41-1.17)	0.17
>5 consultations in the last year (%)	46.32 (44/95)	43.26 (61/141)	1.13 (0.7-1.91)	0.6
Satisfaction with number of consultations (%)	77.89 (74/95)	86.52 (122/141)	0.54 (0.27-1.09)	0.08	0.64 (0.3–1.34)	0.24
Perception of easy contact (%)	82.11 (78/95)	90.07 (127/141)	0.50 (0.23-1.09)	0.07	0.66 (0.27–0.9)	0.05
Satisfaction with gastroenterologist’s care (%)	90.53 (86/95)	95.74 (135/141)	0.42 (0.14-1.24)	0.1
Communication with gastroenterologist via email or text messages (%)	66.32 (63/95)	77.3 (109/141)	0.58 (0.32-1.03)	0.06	0.71 (0.36–1.36)	0.3
Use chronic medication for other indication than IBD (%)	29.47 (28/95)	29.08 (41/141)	1.02 (0.57-1.81)	0.9

IBD: inflammatory bowel disease; IQR: interquartile range; OR: odds ratio; CI: confidence interval. Statistically significant associated variables after the multivariate analysis are shown in bold.