Mean Arterial Pressure Is Related to Incident Nonalcoholic Fatty Liver Disease among the Nonobese Female with Normal Low-Density Lipoprotein Cholesterol Levels: A Large Cohort Study in China
Table 4
Univariate Cox regression analysis for incident nonalcoholic fatty liver disease.
Characteristics
Univariate analysis
Multivariate analysis
HR (95% CI)
value
HR (95% CI)
value
Q1
Ref
Ref
Q2
2.273 (1.921-2.689)
<0.001
1.328 (1.072-1.647)
0.010
Q3
3.613 (3.075-4.245)
<0.001
1.625 (1.276-2.069)
<0.001
Q4
5.083 (4.354-5.934)
<0.001
1.697 (1.231-2.340)
0.001
for trend
<0.001
0.001
Age
1.006 (1.004-1.009)
<0.001
1.008 (1.004-1.011)
0.000
Gender
1.181 (1.088-1.282)
<0.001
0.933 (0.850-1.025)
0.147
BMI
1.815 (1.765-1.866)
<0.001
1.535 (1.485-1.587)
<0.001
SBP
1.023 (1.021-1.025)
<0.001
0.993 (0.988-0.997)
0.002
DBP
1.046 (1.042-1.050)
<0.001
1.007 (0.999-1.016)
0.089
ALP
1.008 (1.007-1.009)
<0.001
1.005 (1.003-1.007)
<0.001
ALT
1.007 (1.006-1.008)
<0.001
1.014 (1.011-1.017)
<0.001
AST
1.009 (1.007-1.011)
<0.001
0.977 (0.968-0.985)
<0.001
ALB
1.005 (0.988-1.021)
0.586
GLB
1.008 (0.997-1.020)
0.166
0.999 (0.987-1.011)
0.860
TB
0.998 (0.989-1.008)
0.695
BUN
0.933 (0.903-0.963)
<0.001
0.828 (0.796-0.862)
<0.001
Cr
1.005 (1.004-1.005)
<0.001
1.002 (1.001-1.004)
<0.001
UA
1.005 (1.005-1.006)
<0.001
0.999 (0.999-1.000)
0.035
FPG
1.297 (1.268-1.327)
<0.001
1.210 (1.170-1.251)
<0.001
TC
1.300 (1.238-1.365)
<0.001
0.776 (0.690-0.872)
<0.001
TG
1.204 (1.192-1.216)
<0.001
1.234 (1.178-1.293)
<0.001
HDL-C
0.278 (0.245-0.316)
<0.001
0.797 (0.664-0.956)
0.014
LDL-C
1.950 (1.774-2.143)
<0.001
1.850 (1.551-2.207)
<0.001
Note: ALB and TB were not included into multivariate analysis for their value more than 0.2 in the univariate cox analysis. Abbreviations: BMI = body mass index; SBP = systolic blood pressure; DBP = diastolic blood pressure; ALP = alkaline phosphatase; ALT = alanine aminotransferase; AST = aspartate aminotransferase; ALB = albumin; GLB = globulin; TB = total bilirubin; BUN = blood urea nitrogen; Cr = creatinine; UA = uric acid; FPG = fasting plasma glucose; TC = total cholesterol; TG = triglyceride; HDL-C = high density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol; HR = hazard ratio; CI = confidence interval.
