Gastroenterology Research and Practice

Research Article

Correlation between Immunohistochemical and Histomorphological Features of Ampullary Carcinomas: A Study on 72 Cases from a Tertiary Health Care Center

Table 2

Gross findingsExtent of spreadMicroscopic findingsImmunohistochemistry
Serial no.Biopsy numberAge/sexClinical detailsRadiological findingsType of specimenPattern of growthSizeMorphologyLocal extent of spreadLymph node involvementArchitectureCell heightNuclear atypiaStromal desmoplasiaImpressionExtentIntensityExtentIntensityInference in IHCCorrelation
12414/1048/FObstructive jaundice for 6 monthsCT shows a small enhancing lesion in D2. Endoscopy shows bulky ampulla with small ulcerWhipple’s specimenIntra-ampullaryNodular massInfiltration into pancreas seen1/6Tubule, trabeculaeLow columnar----Pancreatobiliary3++----PancreatobiliaryPresent
22041/1058/FObstructive jaundice for 3 monthsEndoscopy shows fleshy ampullaWhipple’s specimenIntra-ampullaryNodular massInfiltration into wall of duodenum and bile duct-Tubule, papillae, solid patternTall columnar+--Pancreatobiliary3++----PancreatobiliaryPresent
32208/0944/MJaundice-3 weeksEndoscopy shows nodular massWhipple’s specimenPeriampullaryNodular massInfiltration into wall of duodenum and bile duct—Tubules, papillaeTall columnar+ to +++-Intestinal3+++----Pancreatobiliaryx
41134/1055/FObstructive jaundiceEndoscopy shows prominent ampullaEndoscopic biopsyIntra-ampullary-- -TubulesCuboidal--+Pancreatobiliary3+++---PancreatobiliaryPresent
51937/1059/FJaundice for 3 weeksCT shows periampullary mass with dilated CBDWhipple’s specimenPeriampullaryUlceroproliferative growthInfiltration into duodenal wall and focally in to pancreas-Tubules, papillaeTall columnar++Intestinal----3--IntestinalPresent
61883/0740/MJaundice 1 monthEndoscopy showed a friable prominent ampullaWhipple’s specimenIntra-ampullaryFriable nodular massInfiltration into pancreas and duodenal wall1/4Tubules, cords, and groupsLow columnar+++++Pancreatobiliary3+++----PancreatobiliaryPresent
78707/1072/maleJaundice 2 weeks. Known case of tuberculosisEndoscopy showed a periampullary growthEndoscopic biopsyPeriampullary----Tubules, papillae, focal cribriformLow columnar to tall columnar+ to+++Pancreatobiliary3+++----PancreatobiliaryPresent
88764/1057/maleRecurrent pancreatitis, abdominal pain 6 monthsEndoscopy large ampullary growthEndoscopic biopsyAmpullary1 cmNodular mass—-—-Tubules, papillaeTall columnar++-Intestinal----2+++IntestinalPresent
9S810/1038/maleJaundice 2 weeksEndoscopy polypoid pedunculated massWhipple’s specimenPeriampullaryPolypoid pedunculated mass—2/8Tubules, papillaeLow columnar to tall columnar++++Intestinal/pancreatobiliary3+++2++Intestinal/pancreatobiliaryPresent
10S1184/1078/maleObstructive jaundice, abdominal pain 1 monthUSG-mass in the head of the pancreas, endoscopy-prominent ampullaWhipple’s specimenAmpullaryIll circumscribed firm bulky massInfiltration in to duodenal wall-Tubules, cribriform and solid patternCuboidal to tall columnar+ to ++++Intestinal/pancreatobiliary3+++3++Intestinal/pancreatobiliaryPresent
11S1444/1068/maleLoss of weight, jaundice 1 monthEndoscopy-friable ulcerated ampullaEndoscopic biopsy-----TubulesLow columnar++++Pancreatobiliary3+++----PancreatobiliaryPresent
12S188/0957/maleJaundice, abdominal pain 1 monthEndoscopy-duodenal ulcer with a mass in the ampullary regionWhipple’s specimenPeriampullaryUlcer with raised marginsInfiltration in to duodenal wall and pancreatic parenchyma3/6Tubules, papillaeTall columnar+++Pancreatobiliary/intestinal2++1+Pancreatobiliary/intestinalPresent
13S1264/0752/maleJaundice, loss of weight 1 monthEndoscopy-ulcer in ampullary regionWhipple’s specimenPeriampullaryUlcer in duodenal lumenInfiltration in to duodenal wall3/5Tubules, sheets, and cordsLow columnar to tall columnar++++Pancreatobiliary/intestinal3++1+Pancreatobiliary/intestinalPresent
14S2691/0855/maleAbdominal pain and jaundice for 2 weeksCBD showed an area of hard stricture with occlusion of lumenWhipple’s specimenAmpullary1.5 cmEdema of ampullary mucosa, stricture with occlusion of CBD lumenInfiltration in to wall of duodenum, CBD, pancreas1/5TubulesCuboidal to low columnar+++++Pancreatobiliary1+----PancreatobiliaryPresent
15S3074/0950/maleJaundice, fever, vomiting for 3 monthsEndoscopy-ampullary prominenceWhipple’s specimenAmpullary1.5 cmNodular projection at ampulla—1/1Tubules, papillaeTall columnar+++Intestinal3+++----Intestinalx
16S4966/0965/maleObstructive jaundice 4 monthsCT-dilated CBD and pancreatic ductEndoscopic biopsyIntra-ampullary—Ampullary prominence——Tubules, cribriformLow columnar+++++Pancreatobiliary1------PancreatobiliaryPresent
17S2724/0953/maleJaundice, vomiting 15 daysCT-IHBR dilatation, mass lesion in periampullary region of CBDEndoscopic biopsyPeriampullary----Tubules, cribriformTall columnar++--Intestinal1--1+Pancreatobiliary/intestinalPresent
18S853/0947/maleAbdominal pain, loss of weight, jaundice 2 monthsUSG-dilated CHD, CBD up to terminal endEndoscopic biopsyPeriampullary----TubulesLow columnar++Pancreatobiliary2------PancreatobiliaryPresent
19S1281/0857/maleObstructive jaundice 2 monthsERCP-periampullary growthEndoscopic biopsyPeriampullary----Tubules, cribriformLow columnar++++Pancreatobiliary3------PancreatobiliaryPresent
20S436966/maleItching, loss of appetite 2 monthsEndoscopy-growth in D2, dilated CBDWhipple’s specimenPeriampullary and ampullary—Ulceroproliferative growthInvolve adjacent duodenum pancreatic parenchyma and CBD5/10Papillary, cribriformTall columnar++++Pancreatobiliary3--1+Pancreatobiliary/intestinalx
21S2193/1660/maleObstructive jaundice 4 monthsEndoscopy ampullary growthEndoscopic biopsyIntra-ampullary-Ampullary prominence--Tubules, papillaeLow columnar+++Pancreatobiliary2------PancreatobiliaryPresent
221640/0960/maleItching, abdominal pain, and jaundice for 1 monthUSG-mass in pancreas.
Endoscopy ampullary prominence		Endoscopic biopsyPeriampullary----TubulesCuboidal to low columnar+++Pancreatobiliary-------Intestinalx
23558/0752/maleObstructive jaundiceCT-dilated main pancreatic duct and CBD up to ampulla. No mass lesionEndoscopic biopsyPeriampullary----Tubules, papillaeTall columnar+--Intestinal1+----Pancreatobiliaryx
244267/0970/maleObstructive jaundiceEndoscopy-friable growth ampullary regionEndoscopic biopsyAmpullary----Tubules, papillaeLow columnar to tall columnar++++Pancreatobiliary3+++----PancreatobiliaryPresent
25408451/maleRecurrent pancreatitis 6 monthsEndoscopy ulceration in the periampullary regionWhipple’s specimenPeriampullaryUlcerated lesion with raised borders--Tubules, cribriform, papillaeTall columnar to cuboidal++Intestinal1+2++Pancreatobiliary/intestinalPresent
264675/1056/malePancreatitis, cholecystitis 1 monthDilated IHBRWhipple’s specimenAmpullaryAmpullary prominence-2/8TubulesCuboidal to low columnar+++++Pancreatobiliary3+++----PancreatobiliaryPresent
273826/1065/maleObstructive jaundice 1 monthModerately dilated intra- and extrahepatic biliary channels and pancreatic ductEndoscopic biopsyPeriampullary----Tubules, cribriformLow columnar to cuboidal (mucinous)+++++Pancreatobiliary3+++----PancreatobiliaryPresent
283995/1055/maleObstructive jaundiceERCP-periampullary growthEndoscopic biopsyPeriampullary-Periampullary nodular growth--Tubules, papillaeCuboidal to tall columnar+--Pancreatobiliary/intestinal3+++----Pancreatobiliaryx
29680/1155/maleObstructive jaundiceEndoscopy-periampullary growthWhipple’s specimenPeriampullaryUlceroproliferative growth--Tubules, papillae, cribriformTall columnar to cuboidal+++++Pancreatobiliary/intestinal3 in papillary pattern and negative in tubules+++2 in papillary to 3 in tubules++ to +++Pancreatobiliary/intestinalPresent
302845/1150/maleObstructive jaundiceEndoscopy-periampullary ulceroproliferative growthEndoscopic biopsyPeriampullary-Ulceroproliferative growth--Papillae, tubulesTall columnar++++Pancreatobiliary/intestinal----3++Intestinalx