Research Article
Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer
Table 3
Univariate and multivariate analysis of independent risk factors associated with late recurrence.
| Variable | Early recurrence (<3 yr) () | Late recurrence (≥3 yr) () | Univariate analysis ( value) | Multivariate analysis (OR, 95% CI, value) |
| Age (yr) | | | 0.382 | | <70 | 56 (78.9%) | 24 (88.9%) | | ≥70 | 15 (21.1%) | 3 (11.1%) | 0.726 (0.174–3.024) 0.660 | Gender | | | 0.473 | | Male | 39 (54.9%) | 17 (63.0%) | | 0.996 (0.361–2.747) 0.993 | Female | 32 (45.1%) | 10 (37.0%) | | Tumor location | | | 1.000 | | Right colon | 18 (25.3%) | 7 (25.9%) | | Left colon | 12 (16.9%) | 4 (14.8%) | Rectum | 41 (57.7%) | 16 (59.3%) | Tumor size | | | 0.965 | | <5 cm | 24 (33.8%) | 9 (33.3%) | | ≥5 cm | 47 (66.2%) | 18 (66.7%) | Gross type | | | 0.280 | | Fungating | 30 (42.3%) | 14 (51.9%) | | Infiltrative | 36 (50.7%) | 10 (37.0%) | Unknown | 5 (7.0%) | 3 (11.1%) | Cell type | | | 0.614 | | Nonmucinous | 68 (95.8%) | 25 (92.6%) | | Mucinous | 3 (4.2%) | 2 (7.4%) | Differentiation | | | 0.818 | | WD | 3 (4.2%) | 1 (3.7%) | | MD | 53 (74.6%) | 22 (81.5%) | PD | 15 (21.1%) | 4 (14.8%) | Lymphatic invasion | | | 0.012 | | Absent | 10 (14.1%) | 10 (37.0%) | | Present | 61 (85.9%) | 17 (63.0%) | 0.309 (0.103–0.924) 0.036 | Vascular invasion | | | 1.000 | | Absent | 71 (100%) | 27 (100%) | | Present | 0 (0%) | 0 (0%) | T category | | | 0.193 | | T1 | 0 (0%) | 0 (0%) | | T2 | 1 (1.4%) | 2 (7.4%) | T3 | 67 (94.4%) | 25 (92.6%) | T4 | 3 (4.2%) | 0 (0%) | N category | | | 0.102 | | N0 | 12 (16.9%) | 10 (37.0%) | | N1 | 21 (29.6%) | 6 (22.3%) | N2 | 38 (53.5%) | 11 (40.7%) | Stage | | | 0.051 | | I | 0 (0%) | 1 (3.7%) | | II | 13 (18.3%) | 9 (33.3%) | III | 58 (81.7%) | 17 (63.0%) | 1.315 (0.256–6.753) 0.743 | COX-2 expression | | | 0.001 | | Negative | 45 (63.4%) | 7 (25.9%) | | Positive | 26 (36.6%) | 20 (74.1%) | 4.656 (1.696–12.779) 0.003 |
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