Synergic Interaction of Rifaximin and Mutaflor (Escherichia coli Nissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats

Figure 8

Determination of Muta 5/6 (361 bp), Muta 7/8 (427 bp), and Muta 9/10 (313 bp) amplicons by PCR method as indices of the presence of E. coli Nissle 1917 (EcN). Representative findings in (line 1) control rats without induction of colitis and treated intragastrically (i.g.) with saline; (line 2) rats without induction of colitis and treated i.g. with Mutaflor; (line 3) rats without induction of colitis and treated i.g. with rifaximin; (line 4) rats without induction of colitis and treated i.g. with the combination of rifaximin plus Mutaflor; (line 5) rats treated i.g. with saline after induction of colitis; (line 6) rats treated i.g. with Mutaflor after induction of colitis; (line 7) rats treated i.g. with rifaximin after induction of colitis; and (line 8) rats treated i.g. with the combination of rifaximin plus Mutaflor after induction of colitis. Line M—DNA mass ruler.