TY - JOUR A2 - Kahaleh, Michel AU - Lu, Wenxia AU - Li, Sainan AU - Li, Jingjing AU - Wang, Jianrong AU - Zhang, Rong AU - Zhou, Yuqing AU - Yin, Qin AU - Zheng, Yuanyuan AU - Wang, Fan AU - Xia, Yujing AU - Chen, Kan AU - Liu, Tong AU - Lu, Jie AU - Zhou, Yingqun AU - Guo, Chuanyong PY - 2016 DA - 2016/08/29 TI - Effects of Omega-3 Fatty Acid in Nonalcoholic Fatty Liver Disease: A Meta-Analysis SP - 1459790 VL - 2016 AB - A meta-analysis was conducted to assess the effect of omega-3 fatty acid supplementation (n-3 PUFAs) in lowering liver fat, liver enzyme (alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) levels), and blood lipids (triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), and low density lipoprotein (LDL)) in patients with nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH). Methods. MEDLINE/PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, CINAHL, Science Citation Index (ISI Web of Science), Chinese Biomedical Literature Database (CBM), and Chinese National Knowledge Infrastructure (CNKI) were searched for relevant randomized controlled trials on the effects of n-3 polyunsaturated fatty acids (PUFAs) in patients with NAFLD from inception to May 2015. Ten studies were included in this meta-analysis. Results. 577 cases of NAFLD/NASH in ten randomized controlled trials (RCTs) were included. The results of the meta-analysis showed that benefit changes in liver fat favored PUFA treatment, and it was also beneficial for GGT, but it was not significant on ALT, AST, TC, and LDL. Conclusions. In this meta-analysis, omega-3 PUFAs improved liver fat, GGT, TG, and HDL in patients with NAFLD/NASH. Therefore, n-3 PUFAs may be a new treatment option for NAFLD. SN - 1687-6121 UR - https://doi.org/10.1155/2016/1459790 DO - 10.1155/2016/1459790 JF - Gastroenterology Research and Practice PB - Hindawi Publishing Corporation KW - ER -