Impact of the Siewert Classification on the Outcome of Patients Treated by Preoperative Chemoradiotherapy for a Nonmetastatic Adenocarcinoma of the Oesophagogastric Junction
Table 3
Outcome of patients according to Siewert classification.
Outcome
Siewert 1
Siewert 2
Siewert 3
Siewert 2 + 3
Siewert 1 versus 2 versus 3
Siewert 1 versus (2 + 3)
Mean
OS ± SE (months)
70 ± 11.7
53.2 ± 7.2
61.3 ± 18.8
56.7 ± 7.2
0.18
0.14
Mean
ORR ± SE (%)
27.3 ± 13.4
76.5 ± 8.3
20 ± 17.9
62 ± 7.9
0.052
0.047
Mean
CRLR ± SE (%)
19.2 ± 10.1
41.8 ± 10.1
0
37.5 ± 9.2
0.27
0.35
Mean
CRNR ± SE (%)
0
45.1 ± 10.7
20 ± 17.9
41.3 ± 9.7
0.08
0.028
Mean
CRMR ± SE (%)
9.1 ± 8.7
65.2 ± 9.7
75 ± 21.7
60.2 ± 8.9
0.017
0.012
pCR, (%)
Yes
6 (40)
8 (21.1)
2 (40)
10 (23.3)
0.31
0.21
No
9 (60)
30 (78.9)
3 (60)
33 (76.7)
NA ( = 10)
Cause of death, (%)
Disease progression
2 (33.3)
25 (78.1)
1 (50)
26 (76.5)
0.09
0.06
Complication
3 (50)
3 (9.4)
1 (50)
4 (11.8)
Other causes
1 (16.7)
4 (12.5)
0
4 (11.8)
Cause of death, (%)
Disease progression
2 (33.3)
25 (78.1)
1 (50)
26 (76.5)
0.07
0.03
Other causes
4 (66.7)
7 (21.9)
1 (50)
8 (23.5)
OS: overall survival; ORR: overall relapse rate; SE: standard error; CRLR: cumulative rate of local relapse; CRNR: cumulative rate of nodal relapse; CRMR: cumulative rate of metastatic relapse; pCR: pathological complete response; NA: nonavailable.
