Reference Subjects (study design) Control Treatment Metabolic markers Inflammatory and redox markers Burton-Freeman et al., 2010 [9 ] 24 OW DL (crossover and parallel) HFHCM 960 kcal (fat 30.7 g and CHO 134 g) + placebo matched in sugars with HFHCM. 6 weeks placebo matched in sugars, followed by HFHCM + placebo. HFHCM + strawberry beverage (10 g freeze-dried). 6 weeks strawberry beverage, followed by HFHCM + placebo. TG ↓ TC ↔ TG, TC ↓ OxLDL ↓ OxLDL ↓, Edirisinghe et al., 2011 [10 ] 24 OW DL (crossover) HFHCM 960 kcal (fat 30.7 g and CHO 134 g) + placebo matched in sugars. HFHCM + strawberry beverage (10 g freeze-dried). Glucose ↔ Insulin ↓ IL-6 ↓ IL-1β, TNF-α ↔ Ellis et al., 2011 [11 ] 24 OW (parallel) 6 weeks placebo matched in sugars, followed by HFHCM 960 kcal (fat 30.7 g and CHO 134 g) + placebo. 6 weeks strawberry beverage (10 g freeze-dried), followed by HFHCM + placebo. Glucose, insulin ↔ IL-1β, IL-6, TNF-α ↔
Huebbe et al., 2012 [12 ] 11 OW ATP (crossover) HFM (cream 200 g and sucrose 75 g) + placebo matched in energy, sucrose, fructose, and glucose. HFM + FBD (15% Blackcurrant, 9% raspberry, 7% cherry, and 39% red grape). Glucose, insulin, TG, TC ↔ TNF-α, IL-6 ↑ IL-1 ↔ NEAC ↑ oxLDL ↔ Kay and Holub, 2002 [13 ] 8 (crossover) HFM 853 kcal (fat 46.7 g and CHO 75.2 g) + placebo matched in CHO and contained 76.4 g of glucose. HFM + FBD (100 g freeze-dried wild blueberry powder in 500 mL water). Glucose ↑ TG, TC ↔ NEAC ↑ Mathew et al., 2012 [14 ] 19 (crossover) HFM 691 kcal (50 g fat and CHO 56 g) + placebo matched in energy and energy giving nutrients. HFM + FBD (pomegranate polyphenols 652–948 mg/237 mL). FBD 15 min before the HFM. Glucose, TG, TC ↔ Glucose, TC ↔ TG ↑ Mazza et al., 2002 [15 ] 5 (crossover) HFM 853 kcal (fat 46.7 g and CHO 75.2 g) + placebo matched in CHO and contained 76.4 g of glucose. HFM + FBD (100 g freeze-dried wild blueberry powder in 500 mL water). TG ↔ NEAC ↑ Miglio et al., 2014 [16 ] 14 OW (crossover) HFM 1344 kcal (81 g fat and CHO 104 g) + placebo matched in sugars. HFM + FBD1 (86% of a mix of apple, grape, blueberry, and pomegranate juices and grape skin, grape seed, and green tea extracts). HFM + FBD2 (63% of a mix of pineapple, black currant, and plum juices). NEAC ↑ isoprostanes ↔ NEAC ↔ isoprostanes ↔ Peluso et al., 2012 [17 ] 14 OW (crossover) HFM 1344 kcal (81 g fat and CHO 104 g) + placebo matched in sugars. HFM + FBD (500 mL; 40% pineapple, 18% blackcurrant, and 5% plum). Glucose, insulin, TG, TC ↔ TNF-α, IL-6, IL-17 ↓ Peluso et al., 2014 [18 ] 15 OW (crossover) HFM 1344 kcal (81 g fat and CHO 104 g) + placebo matched in sugars. HFM + FBD (500 mL apple juice, red grape juice, pomegranate juice, grape extract from juice, seeds and pomace, raspberry juice, tea extract, ascorbic acid, apple polyphenols, and lemon flavonoids). Glucose, insulin ↔ TG, TC ↓ TNF-α, IL6 ↓ Snyder et al., 2011 [19 ] 16 (crossover) HCM (28 g of Kellogg's Corn Flakes and 118 mL of 2% milk) + placebo matched in energy, sucrose, fructose, glucose, and ascorbic acid. HCM + navel orange juice (591 mL). NEAC ↑ dienes ↓