[Retracted] Influence of DPYD Genetic Polymorphisms on 5-Fluorouracil Toxicities in Patients with Colorectal Cancer: A Meta-Analysis

Table 1

Main characteristics and methodological quality of all eligible studies.

First author	Year	Country	Ethnicity	Sample	Sample size	Gene	SNP	Clinical indicators	NOS score
Cai [18]	2013	China	Asians	168	Large	DPYD	IVS14+1G>A (rs3918290 G>A)	①③	6
Teh [11]	2013	Malaysia	Asians	26	Small	DPYD	1627A>G (rs1801159 A>G)	②	6
							1896T>C (rs17376848 T>C)
							85T>C (rs1801265 T>C)
							496A>G (rs2297595 A>G)
Deenen [13]	2011	Netherlands	Caucasians	568	Large	DPYD	IVS14+1G>A (rs3918290 G>A)	②③	8
							2194G>A (rs1801160 G>A)
							1627A>G (rs1801159 A>G)
							85T>C (rs1801265 T>C)
Zhang [17]	2011	China	Asians	60	Small	DPYD	464T>A (rs11695471 T>A)	①②	6
							2194G>A (rs1801160 G>A)
							85T>C (rs1801265 T>C)
Kristensen [9]	2010	Denmark	Caucasians	22	Small	DPYD	496A>G (rs2297595 A>G)	①②	5
							1896T>C (rs17376848 T>C)
Zhang [22]	2007	China	Asians	74	Small	DPYD	1627A>G (rs1801159 A>G)	②
							85T>C (rs1801265 T>C)
Raida [23]	2001	Netherlands	Caucasians	25	Small	DPYD	IVS14+1G>A (rs3918290 G>A)	②	6

M: male; F: female; SNP: single-nucleotide polymorphisms; NOS: Newcastle-Ottawa Scale; DPYD: dihydropyrimidine dehydrogenase; ①: marrow suppression; ②: gastrointestinal reaction; ③: hand-foot syndrome.