Review Article
[Retracted] Influence of DPYD Genetic Polymorphisms on 5-Fluorouracil Toxicities in Patients with Colorectal Cancer: A Meta-Analysis
Table 1
Main characteristics and methodological quality of all eligible studies.
| First author | Year | Country | Ethnicity | Sample | Sample size | Gene | SNP | Clinical indicators | NOS score |
| Cai [18] | 2013 | China | Asians | 168 | Large | DPYD | IVS14+1G>A (rs3918290 G>A) | ①③ | 6 |
|
Teh [11] | 2013
| Malaysia | Asians | 26 | Small | DPYD | 1627A>G (rs1801159 A>G) | ② | 6 | 1896T>C (rs17376848 T>C) |
| | | | | | | | 85T>C (rs1801265 T>C) | | | | | | | | | | 496A>G (rs2297595 A>G) | | | Deenen [13] | 2011 | Netherlands | Caucasians | 568 | Large | DPYD | IVS14+1G>A (rs3918290 G>A) | ②③ | 8 | | | | | | | | 2194G>A (rs1801160 G>A) | | | | | | | | | | 1627A>G (rs1801159 A>G) | | |
| | | | | | | | 85T>C (rs1801265 T>C) | | | Zhang [17] |
2011 | China | Asians | 60 | Small | DPYD | 464T>A (rs11695471 T>A) | ①② | 6 | | | | | | | | 2194G>A (rs1801160 G>A) | | |
| | | | | | | | 85T>C (rs1801265 T>C) | | | Kristensen [9] | 2010 | Denmark | Caucasians | 22 | Small | DPYD | 496A>G (rs2297595 A>G) | ①② | 5 | | | | | | | | 1896T>C (rs17376848 T>C) | | |
|
Zhang [22] | 2007 | China | Asians | 74 | Small | DPYD | 1627A>G (rs1801159 A>G) | ② | | 85T>C (rs1801265 T>C) | |
| Raida [23] | 2001 | Netherlands | Caucasians | 25 | Small | DPYD | IVS14+1G>A (rs3918290 G>A) | ② | 6 |
|
|
M: male; F: female; SNP: single-nucleotide polymorphisms; NOS: Newcastle-Ottawa Scale; DPYD: dihydropyrimidine dehydrogenase; ①: marrow suppression; ②: gastrointestinal reaction; ③: hand-foot syndrome.
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