Representative light microscopic appearance of the pancreas in PDH and control groups on day 14 after the induction of PDH. (a) Pancreatic fibrosis was mainly distributed in the interlobular area with a nodular and lobular pattern. Marked infiltration of inflammatory cells was observed mainly in the interlobular area. Inset: representative light microscopic picture of focal fat necrosis. (b) Azan-stained section showed replacement of normal tissue by fatty and connective tissue. (c) Plug formation in the main pancreatic duct. (d) Minimal histological changes were observed in the control group on day 14. (Hematoxylin and eosin staining, original magnification ×25).
