Representative photomicrographs of the pancreas after intraductal infusion of 40 μL/100 g body weight of 0.1% NaTc solution (a), after intraductal infusion of 40 μL of 0.01% agarose (b), or after intraductal infusion of a mixture solution of 0.1% NaTc and 0.01% agarose at amount of 40 μL/100 g body weight (c). (a) On day 14 after intraductal infusion of 40 μL/100 g body weight of 0.1% NaTc solution, the pancreas was histologically normal. (b) On day 14 after intraductal infusion of 40 μL/100 g body weight of 0.01% agarose, the pancreas appeared almost normal. (c) On day 14 after intraductal infusion of a mixture of 0.01% agarose and 0.1% NaTc solution at an amount of 40 μL/100 g body weight, acinar architecture was partially destroyed and replaced by fatty tissues. Dilated pancreatic duct with focal acinar cell necrosis and inflammatory cell infiltration were seen. (Hematoxylin and eosin staining, original magnification ×25).
