Representative photomicrographs of the pancreas after intraductal infusion of 40 μL/100 g body weight of 3% NaTc solution (a) or after intraductal infusion of 50 μL oleic acid (b). (a-left) On day 7 after intraductal infusion of NaTc, acinar architecture was partially destroyed, and infiltration of inflammatory cells was observed. (a-right) On day 14 after intraductal infusion of NaTc, the pancreas recovered with normal histological features (Hematoxylin and eosin staining, original magnification ×25). (b-left) On day 14 after intraductal infusion of oleic acid, acinar architecture was partially destroyed and replaced by fatty tissue. Tubular complexes were surrounded by fatty tissue. (b-right) On day 56 after intraductal infusion of oleic acid, almost all pancreatic parenchymal tissues were replaced by fatty tissue, and only islet cells were observed (Hematoxylin and eosin staining, original magnification ×25).
