Representative photomicrographs of the pancreas after intraperitoneal (ip) injection of 20 μg/kg body weight of Cn (a) or 500 mg/100 g body weight of arginine (b). (a) Seven days after the last Cn injection (on day 35 after the first Cn injection), the pancreas was recovered and histologically normal. (b) On day 28 after the last ip injection of arginine (on day 40 after the first arginine injection), acinar architecture was destroyed with focal acinar cell necrosis. Inset: on day 42 after the last ip injection of arginine (on day 54 after the first arginine injection), acinar tissues were replaced by fatty tissue. (Hematoxylin and eosin staining, original magnification ×25).
