The Role of Dicentric Chromosome Formation and Secondary Centromere Deletion in the Evolution of Myeloid Malignancy

Table 1

Patterns of secondary chromosome aberration derived from 32 primary dicentric (20;var) chromosomes in cases of AML and MDS described in previous publications. In total eleven cases had some mechanism of secondary centromere deletion and had retained or lost the deleted segment, and eight had another type of rearrangement which produced an altered (secondary) dicentric chromosome which retained both chromosomes (four cases had mixtures of clones exhibiting both mechanisms).

Secondary event	MacKinnon and Campbell [3]	MacKinnon et al. [4]	Patsouris et al. [36]	MacKinnon et al. [48]	Total
No change	6	4	1		11
Centromere inactivation	3				3
Intercentromeric deletion	1				1
Inversion reducing intercentromeric distance	3				3
Cases with secondary monocentric chromosomes:
Mixture of clones: intercentromeric deletion/centromere deleted		1			1
Mixture of clones: intercentromeric deletion/centromere excised and retained in a ring chromosome	1				1
Centromere deleted	5				5
Centromere excised and retained in a ring chromosome	2				2
Complex mixture of clones: dicentric and secondary rearrangements (centromere deletion, excision of centric ring, inversion, deletion)		1		1	2
Total	21	6	1	1	29