Review Article

The Role of Dicentric Chromosome Formation and Secondary Centromere Deletion in the Evolution of Myeloid Malignancy

Figure 3

FISH images of three partial metaphases from a case with a dic(16;17) and derivatives formed by loss of the 17 centromere. The normal 17 is also present in each image. (a–c) Blue, chromosomes; red, TP53 (a 17p13 locus); green, whole chromosome 17 paint; (d–f). Each image shows the same view as the image above it but the labelled 17 centromere is visible: blue, 17 centromere; red TP53. (a) (i) a dic(16;17)(q12.1;p13). (b-c) derivatives of the dic(16;17). (b) (ii) a der(16) (the 17 centromere has been lost). (c) (iii) a der(16) and (iv) the deleted segment containing the 17 centromere and TP53. Methods for FISH were as described in MacKinnon et al. [4].
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