The Role of Dicentric Chromosome Formation and Secondary Centromere Deletion in the Evolution of Myeloid Malignancy

Figure 1

Translocations described in the text. (a) Telomere Fusion, creating a dicentric chromosome with minimal DNA loss but potentially causing secondary copy number aberration via the BFB cycle. (b) Dicentric Translocation, a reciprocal translocation producing a dicentric chromosome, and an acentric chromosome which is lost at cell division; (c) Balanced Reciprocal Translocation, producing two monocentric chromosomes—another event is required for CNA to occur. Our model proposes that (a) and (b), which both produce a dicentric chromosome, are the major causes of unbalanced translocation.