Metabolic Causes of Epileptic Encephalopathy

Table 4

Cerebral folate deficiencies.

	Disorder or mechanism
Primary cerebral folate deficiency	Folate receptor FR1 defect due to autoantibodies
	Folate receptor FR1 defect due to (FOLR1 gene) mutation
Disorders with secondary cerebral folate deficiency	Aicardi-Goutieres syndrome
	Alpers syndrome
	Isolated Rett syndrome
	Kearns-Sayre syndrome
	Mitochondrial complex I encephalomyopathy
	Valproic acid complications