Metabolic Causes of Epileptic Encephalopathy

Table 3

Mitochondrial disorders and epilepsy.

Category of disorder	Syndrome
Mitochondrial complex deficiencies	(i) Complex I deficiency; (ii) Complex II deficiency; (iii) Complex III deficiency; (iv) Complex IV deficiency; (v) Complex V deficiency
Mitochondrial DNA disorders	(i) mtDNA depletion syndromes; (a) POLG1 disease; (1) Alpers-Huttenlocher disease; (2) Childhood onset epilepsia partialis continua (EPC); (3) Myoclonic epilepsy myopathy sensory ataxia (MEMSA); (ii) mtDNA deletion syndromes; (a) Kearns-Sayre syndrome (KSS); (b) Chronic progressive external ophthalmoplegia (CPEO); (iii) Myoclonic epilepsy with ragged-red fibers (MERRF); (iv) Myoclonic epilepsy, lactic acidosis, and stroke (MELAS)
Other associated syndromes	Leigh syndrome