Computational Approach to Identify Enzymes That Are Potential Therapeutic Candidates for Psoriasis

Table 3

Nonsynonymous SNPs of ZAP70.

rsNumber	DNA substitution	Amino-acid substitution	Overall stability	Predicted ΔΔG (kcal/mol)
rs56077145	106C > G	Leu36Val	Destabilising	−1.03
rs113994172	239C > A	Pro80Gln	Stabilising	0.82
rs56264206	308A > T	Asn103Ile	Stabilising	0.71
rs55845489	309C > A	Asn103Lys	Destabilising	−0.36
rs55679020	311G > C	Arg104Pro	Stabilising	0.11
rs111771234	550T > A	Phe115Ile	Stabilising	0.67
rs55964305	524G > T	Arg175Leu	Destabilising	−0.67
rs56403250	572C > T	Pro191Leu	Stabilising	0.08
rs76059124	653C > T	Ala218Val	Destabilising	−1.86
rs113310375	1274T > C	Val356Ala	Destabilising	−2.01
rs113994174	1393C > T	Arg465Cys	Destabilising	−0.81
rs56059280	1468G > A	Asp490Asn	Destabilising	−0.29
rs104893674	1554C > A	Ser518Arg	Destabilising	−0.56
rs56189815	1568G > T	Trp523Leu	Stabilising	3.36
rs56146954	1580T > G	Val527Gly	Destabilising	−4.09
rs113994175	1714A >T	Met572Leu	Stabilising	0.17
rs55803111	1781G > A	Arg594Gln	Stabilising	1.11
rs56326640	1783G > T	Ala595Ser	Destabilising	−0.36
rs56250717	1826G > A	Gly609Asp	—	—