Natural compounds from various organisms have been shown to possess health benefits for humans. According to the estimation of the World Health Organization, in developing countries, 80% of the population still depends on traditional medicines which are mostly prepared from plants for the prevention or treatment of various diseases. Diabetes is one of the chronic diseases of metabolism and is upsurging across every continent in the world. Treatment to prevent this disease is an important challenge for researchers.

Conventional drugs for the treatment of this disease improve insulin sensitivity. However, they have additional side effects and do not always provide satisfactory results. Bioactive compounds from plants are a paramount source for potential lead candidates’ discovery, which can play an utmost role in drug discovery and drug development projects. They are an alternative source to overcome this problem as they contain various phytocompounds which show protective effects against diabetics. The application of bioactive constituents from plants in the pharmaceutical industry has increased significantly. In addition to this, bioactive compounds are considered suitable candidates for drug development due to their pleiotropic actions on target locations with multiple outcomes. Plant-derived nanomaterials have also shown potential application in diabetes management. Hence, research into bioactive compounds and nanomaterials from plants may contribute to the development of effective and novel alternative therapeutics in the search for side effects, eco-friendly, low-cost, fast, and diabetes treatment drugs.

This Special Issue aims to collect original research and review articles regarding research into bioactive compounds in diabetes prevention.

Potential topics include but are not limited to the following:

• Assessment of antidiabetic properties of household plants
• Medicinal plants in diabetes prevention
• Natural products to prevent drug resistance in diabetes
• Role of herbs in diabetes management
• In-vitro studies in the evaluation of antidiabetic agents
• In-silico studies of bioactive compounds against diabetes receptors
• Prospects and paradigms of plant-based product mediated diabetes treatment
• Synergistic effects of bioactive compounds in diabetics
• Biomarkers targeted for plant-derived antidiabetic drug development
• In-vivo studies in developing antidiabetic agents
• Functional foods for the management of pre-diabetic conditions
• Wild edible plants in diabetes management
• Plant-derived nanomaterials for diabetes management