The effective ingredients of Chinese herbal medicine (CHM) compounds can affect the progress of tumors at the epigenetic level and can have an effect in different pathological stages of tumors. Active ingredients and mechanisms have multiple pathways and multiple targets.

At present, there is insufficient basic research, unclear intervention effects and mechanisms on the dynamic process of disease, and relatively isolated research on various factors of epigenetic modification. In-depth research is still needed, and the results will be transformed into clinical applications.

The purpose of this Special Issue is to gather original research and review articles on the activity and mechanism of traditional Chinese medicine molecules and to provide high-quality evidence on the mechanism of action of Chinese herbal medicines and monomer drugs in the treatment of tumors. Systematic reviews are particularly welcome.

Potential topics include but are not limited to the following:

• The efficacy and mechanism of CHM in the treatment of tumors (such as tumors of the gastrointestinal system, nervous system, respiratory system, bone tumors, gynecological tumors, urinary system, etc.)
• Studies of the mechanism of CHM in treating tumors in vivo and in vitro
• Evaluation of toxicity of Traditional Chinese Medicine in treating tumors
• Extraction and reconstruction of new types of Chinese Medicine in treating tumors
• Pharmacokinetic analysis of new Chinese medicines and small molecule drugs in treating tumors
• Safety and effectiveness of new Chinese medicine and small molecule drugs in the treatment of tumors