Alternative therapies with natural products are not generally considered part of conventional medicine. Alternative medicines have been in practice since ancient times and are practiced worldwide even today, as there is always a search for new treatment strategies with clinical efficacy, greater biocompatibility, lower cost, less toxicity and greater acceptance.

However, it is necessary to assess the quality of scientific evidence that supports the application of any alternative therapy to be considered safe and effective. In the last years, there has been an increase in biotechnology applied to formulations, including drug delivery systems. This advance is the result of constant research efforts in industry and academic institutions searching for more specific drug targeting and delivery systems for the design of new materials. Some of the drug delivery systems are designed to overcome antimicrobial resistance, for example. In the case of natural products, the structural and physicochemical properties may create challenges in the development of the pharmaceutical product.

Therefore, it is important to highlight that the development of drug delivery systems with natural products is still quite limited. The aim of this Special Issue is to invite investigators to contribute original papers in this field, sharing the scientific evidence and the efficacy of them. We highly encourage submissions of review articles too.

Potential topics include but are not limited to the following:

• Drug design, development and delivery systems for natural products
• In vitro and in vivo studies of all drug delivery systems with natural products
• Drug clinical trial studies in the field of drug delivery with natural products
• Drug delivery properties, manufacturing processes, and quality control studies
• Microcapsules, liposomes, vesicles, and macromolecular conjugates
• Physicochemical and chemical methods in drug delivery systems
• Progress in the fields of transport and mechanisms of drug delivery of natural products
• Multi-drug resistance and drug delivery systems with natural products
• Systematic reviews and meta-analyses
• Innovative aspects of drug delivery system with natural products
• Bioavailability and drug delivery systems for natural products
• Adverse events of drug delivery systems for natural products