Antidepressant-Like Activity and Molecular Docking Analysis of a Sesquiterpene Lactone Isolated from the Root Bark of Ximenia americana (L.)

Table 1

Results of the open field test in mice treated with Ximenia americana root bark extract.

Test samples, p.o	Number of crossings
	Peripheral squares	Central squares	Total squares
Vehicle	69.17 ± 3.36^a	7.17 ± 1.92^a	76.34 ± 5.28^a
Extract (100 mg/kg)	73.50 ± 2.14^a	5.83 ± 1.13^a	79.33 ± 3.17^a
Extract (200 mg/kg)	75.50 ± 2.32^a	8.00 ± 1.06^a	83.50 ± 3.38^a
Extract (400 mg/kg)	77.83 ± 2.62^a	5.50 ± 1.17^a	83.33 ± 3.79^a
Imipramine (30 mg/kg)	72.17 ± 2.44^a	8.50 ± 2.04^a	80.67 ± 4.48^a

Note. Values are presented as mean ± SEM; n = 6; vehicle: received 2% Tween-80 in distilled water; data were analyzed by one-way ANOVA followed by Tukey post hoc test; data followed by same letters within column are not significantly different at ; p.o: per oral.