Validation of Antidiabetic and Antihyperlipidemic Effects of 80% Methanolic Extract of the Lonchocarpus laxiflorus Leaves in Streptozotocin-Induced Diabetic Swiss Albino Mice

Table 5

The effect of repeated daily dose of the crude extract on the serum lipid level of diabetic mice.

Serum lipid level (mg/dl)
Dose	TC	TG	LDL-C	VLDL-C	HDL-C
DNC	192.41 ± 1.60^b3	155.69 ± 2.84	102.33 ± 3.34^b3	35.26 ± 1.49^b3	25.73 ± 1.82
GCL 5 mg/kg	118.12 ± 4.14^a3	83.59 ± 1.92^a3	48.77 ± 1.07^a3	21.13 ± 1.01^a3	44.65 ± 1.31^a3
CE100 mg/kg	168.17 ± 3.92^b3	149.62 ± 3.11^b3	90.37 ± 2.38^b3	38.03 ± 0.41^b3	30.67 ± 1.54^b3
CE200 mg/kg	128.17 ± 1.18^a3	89.31 ± 3.18^a3	51.53 ± 1.56^a3	25.68 ± 0.57^a2	36.31 ± 1.02^a3
CE 400 mg/kg	121.04 ± 0.69^a3	86.59 ± 1.54^a3	48.73 ± 1.53^a3	23.51 ± 0.62^a3	39.58 ± 0.57^a3
NNC	115.43 ± 3.25^a3	78.75 ± 2.33^a3	41.08 ± 1.05^a3	19.93 ± 0.42^a3	45.35 ± 1.23^a3

Each value represents mean ± SEM (n = 6 mice in each group) and analyzed by one-way ANOVA followed by Post Hoc Tukey’s test; ^acompared to the diabetic control, ^bcompared to the normal control; ¹ < 0.05, ² < 0.01, and ³ < 0.001. TC = Total cholesterol, TG = triacylglycerol (TG), VLDL-C = verylow-density lipoprotein cholesterol, LDL-C = low-density lipoprotein cholesterol, HDL-C = high-density lipoprotein cholesterol, CE = crude extract, DNC = diabetes negative control that received 10 ml/kg 2% tween 80 in distilled water GLC = glibenclamide, NNC = normal negative control that received 10 ml/kg 2% tween 80 in distilled water.