Pharmacology Mechanism of Polygonum Bistorta in Treating Ulcerative Colitis Based on Network Pharmacology

Table 2

The core targets of PB and UC.

Gene names	Protein name	UniProt ID	Degree	Compositions of PB
MMP2	72 kDa type IV collagenase	P08253	50	Quercetin, ellagic acid
MMP9	Matrix metalloproteinase-9	P14780	62	Quercetin, ellagic acid
NFKBIA	NF-kappa-B inhibitor alpha	P25963	48	Quercetin, ellagic acid
CXCL8	Ubiquitin carboxyl-terminal hydrolase 17	Q6R6M4	60	Quercetin, ellagic acid
PTGS2	Prostaglandin G/H synthase 2	P35354	64	(+)-catechin, quercetin, ellagic acid, ZINC04073977, beta-sitosterol
JUN	Transcription factor AP-1	P05412	67	Quercetin, beta-sitosterol
CASP3	Caspase-3	P42574	68	Quercetin, beta-sitosterol
PPARG	Peroxisome proliferator-activated receptor gamma	P37231	57	Quercetin, poriferast-5-en-3beta-o, beta-sitosterol
EGFR	Epidermal growth factor receptor	P00533	60	Quercetin, ellagic acid
AKT1	RAC-alpha serine/threonine-protein kinase	P31749	78	Quercetin, ellagic acid
CCND1	G1/S-specific cyclin-D1	P24385	56	Quercetin
FOS	Proto-oncogenec-Fos	P01100	56	Quercetin
TP53	Cellular tumor antigen p53	P04637	75	Quercetin
HIF1A	Hypoxia-inducible factor 1-alpha	Q16665	63	Quercetin
MYC	Myc proto-oncogene protein	P01106	61	Quercetin
ICAM1	Intercellular adhesion molecule 1	P05362	48	Quercetin
IL1B	Interleukin-1 beta	P01584	70	Quercetin
CCL2	C-C motif chemokine 2	P13500	55	Quercetin